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Copper allergy triggered by a copper IUD birth control device, exacerbated by an accidental steroid overdose. Episode 6: "The Socratic Method" Original Air Date: December 21, 2004
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Carly, an ambitious corporate executive who experiences intense leg pain and sudden paralysis. Diagnosis: Idiopathic upper thigh carcinoma.
Matt, a high school student who collapses during an exam, followed shortly after by another student with identical symptoms.
A high-powered corporate executive hides an intense, self-harming eating disorder while suffering from intense leg pain.
Beyond the medical cases, the season's primary arc involves billionaire Edward Vogler
Later seasons added and removed team members (Thirteen, Kutner, Taub). But Season 1’s Foreman, Chase, and Cameron are perfectly balanced:
The diagnosis requires an admission of infidelity, as the disease is sexually transmitted and she has never left the country, forcing a confession that ruins her marriage. Episode 8: "Poison" Original Air Date: January 25, 2005
Introduces House’s reliance on Vicodin, his cane, and the core philosophy that patients lie to protect themselves. Episode 2: "Paternity" Original Air Date: November 23, 2004
(May 3, 2005) – The Case: A young diver is diagnosed with a thyroid storm, but House suspects that the dive wasn't the only thing impacting her body.
Varied, but culminates in House's own diagnosis: Infarction/aneurysm in the thigh leading to muscle necrosis.
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ControlThe introduction of billionaire Edward Vogler, who becomes the hospital's chairman and House’s primary antagonist for the rest of the season.